Rabe Katja, Lehrke Michael, Parhofer Klaus G, Broedl Uli C
Department of Internal Medicine II, University of Munich, Munich, Germany.
Mol Med. 2008 Nov-Dec;14(11-12):741-51. doi: 10.2119/2008-00058.Rabe. Epub 2008 Sep 17.
Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system--thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-alpha and interleukin-6, vaspin, and visfatin on insulin resistance.
肥胖与成人及儿童群体中的一系列健康问题相关。在过去几十年里，对肥胖及其代谢后遗症发病机制的认识有了迅速进展。脂肪组织是一个活跃的内分泌器官，除了调节脂肪量和营养稳态外，还释放大量生物活性介质（脂肪因子），这些介质向包括脑、肝、骨骼肌和免疫系统在内的具有代谢重要性的器官发出信号，从而调节止血、血压、脂质和葡萄糖代谢、炎症以及动脉粥样硬化。在本综述中，我们总结了目前关于脂肪组织衍生激素脂联素、chemerin、瘦素、网膜素、抵抗素、视黄醇结合蛋白4、肿瘤坏死因子-α和白细胞介素-6、vaspin和内脂素对胰岛素抵抗影响的数据。
