运动神经元对 proBDNF 的反应程序性细胞死亡。
Motoneuron programmed cell death in response to proBDNF.
机构信息
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
出版信息
Dev Neurobiol. 2012 May;72(5):699-712. doi: 10.1002/dneu.20964.
Abstract
Motoneurons (MN) as well as most neuronal populations undergo a temporally and spatially specific period of programmed cell death (PCD). Several factors have been considered to regulate the survival of MNs during this period, including availability of muscle-derived trophic support and activity. The possibility that target-derived factors may also negatively regulate MN survival has been considered, but not pursued. Neurotrophin precursors, through their interaction with p75(NTR) and sortilin receptors have been shown to induce cell death during development and following injury in the CNS. In this study, we find that muscle cells produce and secrete proBDNF. ProBDNF through its interaction with p75(NTR) and sortilin, promotes a caspase-dependent death of MNs in culture. We also provide data to suggest that proBDNF regulates MN PCD during development in vivo.
摘要
运动神经元（MN）和大多数神经元群体都经历一个特定的时间和空间的程序性细胞死亡（PCD）时期。有几个因素被认为可以调节 MN 在这段时间内的存活，包括肌肉衍生的营养支持和活动的可用性。人们已经考虑到靶源性因子也可能负调控 MN 存活的可能性，但没有进一步研究。神经营养因子前体通过与 p75（NTR）和分选素受体的相互作用，在中枢神经系统的发育过程中和损伤后被证明会诱导细胞死亡。在这项研究中，我们发现肌肉细胞产生和分泌 proBDNF。proBDNF 通过与 p75（NTR）和分选素的相互作用，促进培养中的 MN 发生 caspase 依赖性死亡。我们还提供的数据表明，proBDNF 在体内发育过程中调节 MN 的 PCD。
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