Department of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas at Austin, Austin, Texas 78712, USA.
Org Lett. 2011 Sep 2;13(17):4542-5. doi: 10.1021/ol201739u. Epub 2011 Aug 11.
Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine.
已经开发了几种新型的多组分组装工艺,用于快速有效地组装具有四氢异喹啉核心的各种杂环支架,其中每个都可以轻松衍生化以获得各种化合物。这项工作导致了一种新的合成稠合喹唑啉酮环系统的方法的偶然发现,该方法被应用于喹唑啉咔啉生物碱 ruteecarpine 的一步全合成。