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通过多组分反应-分子内环加成方法合成稠合 1,2,3-三唑的进展。

Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach.

机构信息

Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695019, India.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

出版信息

Molecules. 2022 Dec 30;28(1):308. doi: 10.3390/molecules28010308.

DOI:10.3390/molecules28010308
PMID:36615500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9821980/
Abstract

The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)-intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate azide and alkyne functionalities in the MCR product which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction. We have aimed at a critical discussion and also have highlighted either advantages or disadvantages of each methodology.

摘要

本文综述了几篇报道，这些报道涉及通过顺序多组分反应（MCR）-分子内环加成（IAAC）方法合成含融合 1,2,3-三唑的支架。所综述的反应经过精心设计，以便在 MCR 产物中引入叠氮和炔基官能团，然后进行 IAAC。综述根据多组分反应中组分的数量分为两部分。我们旨在进行批判性讨论，并强调每种方法的优点或缺点。

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