(+)-山梨醇菌素 A 的全合成。
Formal synthesis of (+)-sorangicin A.
机构信息
Kenan, Caudill, Venable, and Murray Laboratories of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
出版信息
Org Lett. 2011 Sep 2;13(17):4712-5. doi: 10.1021/ol201920j. Epub 2011 Aug 11.
Abstract
The formal synthesis of (+)-sorangicin A was completed by two independent routes. Both approaches feature a cross metathesis reaction to form the C29-C30 bond to arrive at the bicyclic ether/tetrahydropyran fragment. Formation of the C15-C16 olefin to unite the dihydropyran fragment with the rest of the molecule was achieved by either a cross metathesis reaction or a Julia-Kocienski olefination.
摘要
（+）-桑辛素 A 的全合成是通过两条独立的路线完成的。这两种方法都采用交叉复分解反应形成 C29-C30 键，得到双环醚/四氢吡喃片段。通过交叉复分解反应或 Julia-Kocienski 烯烃化反应形成 C15-C16 双键，将二氢吡喃片段与分子的其余部分连接起来。
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