Molecular Nanofabrication Group, MESA+ Institute for Nanotechnology, University of Twente , P.O. Box 217, 7500AE, Enschede, The Netherlands.
Langmuir. 2011 Sep 20;27(18):11508-13. doi: 10.1021/la202346r. Epub 2011 Aug 22.
Specific (host-guest) and unspecific (substrate-guest) interactions between self-assembled monolayers of cucurbit[7]uril (CB[7]) on gold (Au) substrates and neutral adamantyl (Ad) guests were resolved by studying these interactions at the single molecule level using dynamic force spectroscopy. The dissociation rate constants of the Ad-Au and the Ad-CB[7] interactions were 0.3 s(-1) and 0.03 s(-1), respectively, indicating that the specific binding is more stable. The probability of observing a specific interaction (40 ± 9%) is similar to the reported surface coverages of CB[7] monolayers on Au substrates. The higher strength and stability of the Ad-CB[7] interactions explains why, although presenting an imperfect coverage, CB[n] monolayers can be used successfully as a platform for surface immobilization.
通过使用动态力光谱法在单分子水平上研究这些相互作用，解析了金（Au）基底上葫芦[7]脲（CB[7]）自组装单层与中性金刚烷（Ad）客体之间的特定（主体-客体）和非特定（基质-客体）相互作用。Ad-Au 和 Ad-CB[7]相互作用的解离速率常数分别为 0.3 s(-1)和 0.03 s(-1)，表明特定结合更稳定。观察到特定相互作用的概率（40 ± 9%）与报道的 Au 基底上 CB[7]单层的表面覆盖率相似。Ad-CB[7]相互作用的强度和稳定性更高，解释了为什么尽管覆盖率不完美，但 CB[n]单层仍可成功用作表面固定化的平台。
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