Yuan Huanxiang, Jia Shaochuan, Li Zelin, Liu Jian, Wang Xiaoyu, Qi Ruilian
Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100090, China.
Nanomaterials (Basel). 2022 Aug 24;12(17):2905. doi: 10.3390/nano12172905.
An intelligent "antimicrobial switch" has been constructed to reduce prolonged exposure of pathogenic bacteria to antibiotics, which could reversibly "turn off" or "turn on" the antimicrobial activity of hemicyanines through self-assembly or dis-assembly of cucurbit[7]uril (CB[7]). This assembly effectively inhibited the production of ROS under light, shielding the active site of hemicyanines and achieving on-demand antimicrobial ability. Moreover, CB[7] differentially inhibits ROS of molecules with different alkyl chain lengths, which provided reference for the subsequent design of materials with antimicrobial activity regulation, and could effectively delay or even prevent the development of pathogens resistance.
一种智能“抗菌开关”已被构建出来，以减少病原菌对抗生素的长时间暴露，它可以通过葫芦[7]脲（CB[7]）的自组装或拆卸来可逆地“关闭”或“开启”半菁的抗菌活性。这种组装有效地抑制了光照下活性氧的产生，屏蔽了半菁的活性位点并实现了按需抗菌能力。此外，CB[7]对不同烷基链长度的分子的活性氧有不同程度的抑制作用，这为后续设计具有抗菌活性调控功能的材料提供了参考，并且可以有效地延缓甚至防止病原体耐药性的发展。
