Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh.
Nat Prod Res. 2012;26(11):979-86. doi: 10.1080/14786419.2010.535166. Epub 2011 Aug 11.
The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities. Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3). This is the first report of isolation of compounds (1) and (2) from P. chaba. It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC₅₀ values of 0.76 and 0.83 µg mL⁻¹, respectively. These compounds were also found to have weak antibacterial and antileishmanial activities. This is the first report about the antileishmanial activity of Piper isolates.
荜茇根的石油醚和氯仿提取物表现出抗菌、抗利什曼原虫和细胞毒性活性。进一步的基于生物活性的分离导致了对桦木脂素胡椒酯（1）、胡椒隆宁碱（2）和胡椒碱（3）的分离。这是首次从荜茇中分离出化合物（1）和（2）的报道。观察到分离出的化合物（1 和 2）在与标准药物制霉菌素相比时表现出很强的抗真菌活性，并且具有显著的细胞毒性活性，其 IC₅₀ 值分别为 0.76 和 0.83 μg mL⁻¹。这些化合物还具有较弱的抗菌和抗利什曼原虫活性。这是关于胡椒属植物抗利什曼原虫活性的首次报道。
