Oliveira Flávio Augusto de Souza, Passarini Guilherme Matos, Medeiros Daniel Sol Sol de, Santos Ana Paula de Azevedo, Fialho Saara Neri, Gouveia Aurileya de Jesus, Latorre Marcinete, Freitag Elci Marlei, Medeiros Patrícia Soares de Maria de, Teles Carolina Bioni Garcia, Facundo Valdir Alves
Departamento de Biomedicina, Faculdade de Educação e Cultura de Vilhena, Vilhena, RO, Brasil.
Plataforma de Bioensaios em Malária e Leishmaniose/Fundação Oswaldo Cruz - Rondônia, Porto Velho, RO, Brasil.
Rev Soc Bras Med Trop. 2018 May-Jun;51(3):382-386. doi: 10.1590/0037-8682-0309-2017.
This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis.
The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured.
Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity.
The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.
本研究评估了来自糙叶胡椒的化合物对恶性疟原虫和圭亚那利什曼原虫的活性。
测定了糙叶胡椒果实中的化合物对恶性疟原虫和圭亚那利什曼原虫前鞭毛体体外生长的影响。测量了其对HepG2和J774细胞的溶血作用和细胞毒性。
三种化合物表现出较强的抗疟活性，一种化合物表现出较强的抗利什曼原虫活性。两种化合物对HepG2细胞无毒，而所有化合物对J774细胞均有毒性。这些化合物没有溶血活性。
所测试的糙叶胡椒化合物具有抗寄生虫和细胞毒性作用。
