David H
Institut für Pathologische Anatomie Bereichs Medizin, Humboldt-Universität zu Berlin, DDR.
Zentralbl Allg Pathol. 1990;136(1-2):15-32.
Review is made to an account of contemporary knowledge on cell organelles in an attempt to describe organellopathies known at present together with their relations with diseases and syndromes. Organellopathy is defined as a disease, with its primary effect and/or primary morphological and functional alterations being located in the organelle population of one or several cell types. Mitochondriopathies (mitochondrial disorders), lysosomopathies (lysosomal disease), peroxisomopathies (peroxisomal disorders), ciliopathies (ciliary diseases), and plasma membranopathies (brush border membrane diseases) have so far been most comprehensively characterised and are associated with distinctive clinical pictures. However, unambiguously characterised pathies are almost completely absent with regard to other organelles. With numerous ideas still being of speculative nature, the concept of organellopathies as such may be considered as an element of modern cellular pathology.
本文回顾了有关细胞器的当代知识，试图描述目前已知的细胞器病及其与疾病和综合征的关系。细胞器病被定义为一种疾病，其主要影响和/或主要形态和功能改变位于一种或几种细胞类型的细胞器群体中。线粒体病（线粒体疾病）、溶酶体病（溶酶体疾病）、过氧化物酶体病（过氧化物酶体疾病）、纤毛病（纤毛疾病）和质膜病（刷状缘膜疾病）迄今为止已得到最全面的表征，并与独特的临床症状相关。然而，关于其他细胞器，几乎完全没有明确表征的病症。由于许多观点仍具有推测性，细胞器病这一概念本身可被视为现代细胞病理学的一个要素。
