追踪应激的分子底物：p38α MAPK 和 κ 阿片受体的新作用。
Tracking down the molecular substrates of stress: new roles for p38α MAPK and kappa-opioid receptors.
机构信息
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA.
出版信息
Neuron. 2011 Aug 11;71(3):383-5. doi: 10.1016/j.neuron.2011.07.018.
Abstract
In this issue, Bruchas et al. (2011) uncover a novel stress-induced p38α MAPK signaling cascade within serotonergic neurons of the dorsal raphe nucleus that mediates depressive and drug-seeking behaviors. Their findings have potentially important implications for medication development.
摘要
在本期中，Bruchas 等人（2011）揭示了一个在背缝核中 5-羟色胺能神经元内新型的应激诱导的 p38α MAPK 信号级联，该信号级联介导了抑郁和觅药行为。他们的研究结果对药物开发具有潜在的重要意义。
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