5-羟色胺 2C 受体通过 TRPC 通道激活弓状核前阿黑皮素原神经元的一个独特群体。
Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.
机构信息
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
出版信息
Neuron. 2011 Aug 11;71(3):488-97. doi: 10.1016/j.neuron.2011.06.012.
Abstract
Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.
摘要
5-羟色胺 2C 受体（5-HT2CRs）表达在下丘脑弓状核的 pro-opiomelanocortin（POMC）神经元中，调节摄食、能量平衡和葡萄糖代谢。然而，5-HT 通过 5-HT2CR 调节 POMC 神经元活性的细胞机制尚未确定。在本研究中，我们发现，假定的瞬时受体电位 C（TRPC）通道介导了 mCPP（5-HT2CR 激动剂）对 POMC 神经元亚群的激活。有趣的是，mCPP 激活的 POMC 神经元与由瘦素激活的神经元是不同的群体。总之，我们的数据表明，5-HT2CR 和瘦素受体由弓状核 POMC 神经元的不同亚群表达，5-HT 和瘦素都通过 TRPC 通道在 POMC 神经元中发挥作用。
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