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弓状核POMC和NPY/AgRP神经元表达的GIRK1钾通道的细胞和代谢功能。

Cellular and metabolic function of GIRK1 potassium channels expressed by arcuate POMC and NPY/AgRP neurons.

作者信息

Choi Yeeun, Yoo Eun-Seon, Oh Youjin, Sohn Jong-Woo

机构信息

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.

出版信息

Mol Cells. 2024 Nov;47(11):100122. doi: 10.1016/j.mocell.2024.100122. Epub 2024 Oct 5.

DOI:10.1016/j.mocell.2024.100122
PMID:39374791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11567913/
Abstract

It is well known that the G protein-gated inwardly rectifying K (GIRK) channels are critical to maintain excitability of central neurons. GIRK channels consist of 4 subunits and GIRK1/GIRK2 heterotetramers are considered to be the neuronal prototype. We previously reported the metabolic significance of GIRK2 subunits expressed by the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARH). However, the role of GIRK1 subunits expressed by the neurons of ARH remains to be determined. In this study, we delineated the contribution of GIRK1 channel subunits to the excitability of the pro-opiomelanocortin (POMC) and NPY/AgRP neurons of the ARH. We further assessed the metabolic function of GIRK1 subunits expressed by these neurons. Our results provide insight into how GIRK channels regulate arcuate POMC and NPY/AgRP neurons and shape metabolic phenotypes.

摘要

众所周知，G蛋白门控内向整流钾通道（GIRK通道）对于维持中枢神经元的兴奋性至关重要。GIRK通道由4个亚基组成，GIRK1/GIRK2异源四聚体被认为是神经元原型。我们之前报道了下丘脑弓状核（ARH）中神经肽Y（NPY）/刺鼠相关肽（AgRP）神经元所表达的GIRK2亚基的代谢意义。然而，ARH神经元所表达的GIRK1亚基的作用仍有待确定。在本研究中，我们阐述了GIRK1通道亚基对ARH中阿黑皮素原（POMC）和NPY/AgRP神经元兴奋性的贡献。我们进一步评估了这些神经元所表达的GIRK1亚基的代谢功能。我们的结果为GIRK通道如何调节弓状核POMC和NPY/AgRP神经元以及塑造代谢表型提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/11f18d499c2a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/8ddf05679841/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/d5432a5e0c4d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/1f7aeb1932b5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/83eb7f517784/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/9f959df9003e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/fbb68c361590/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/5709643837f4/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/11f18d499c2a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/8ddf05679841/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/d5432a5e0c4d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/1f7aeb1932b5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/83eb7f517784/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/9f959df9003e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/fbb68c361590/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/5709643837f4/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5553/11567913/11f18d499c2a/gr8.jpg

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