Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nangjing, Jiangsu Province 210002, China.
Eur J Radiol. 2012 Aug;81(8):1766-75. doi: 10.1016/j.ejrad.2011.06.057. Epub 2011 Aug 10.
To evaluate the correlation between quantitative dual energy CT and perfusion CT measurements in rabbit VX2 liver tumors.
This study was approved by the institutional animal care and use committee at our institution. Nine rabbits with VX2 liver tumors underwent contrast-enhanced dual energy CT and perfusion CT. CT attenuation for the tumors and normal liver parenchyma and tumor-to-liver ratio were obtained at the 140kVp, 80kVp, average weighted images and dual energy CT iodine maps. Quantitative parameters for the viable tumor and adjacent liver were measured with perfusion CT. The correlation between the enhancement values of the tumor in iodine maps and perfusion CT parameters of each tumor was analyzed. Radiation dose from dual energy CT and perfusion CT was measured.
Enhancement values for the tumor were higher than that for normal liver parenchyma at the hepatic arterial phase (P<0.05). The highest tumor-to-liver ratio was obtained in hepatic arterial phase iodine map. Hepatic blood flow of the tumor was higher than that for adjacent liver (P<0.05). Enhancement values of hepatic tumors in the iodine maps positively correlated with permeability of capillary vessel surface (r=0.913, P<0.001), hepatic blood flow (r=0.512, P=0.010), and hepatic blood volume (r=0.464, P=0.022) at the hepatic arterial phases. The effective radiation dose from perfusion CT was higher than that from DECT (P<0.001).
The enhancement values for viable tumor tissues measured in iodine maps were well correlated to perfusion CT measurements in rabbit VX2 liver tumors. Compared with perfusion CT, dual energy CT of the liver required a lower radiation dose.
评估兔 VX2 肝肿瘤的定量双能 CT 与灌注 CT 测量值之间的相关性。
本研究经机构动物护理和使用委员会批准。9 只兔 VX2 肝肿瘤患者行增强双能 CT 和灌注 CT 检查。在 140kVp、80kVp、平均加权图像和双能 CT 碘图上获得肿瘤和正常肝实质的 CT 衰减值及肿瘤与肝比值。用灌注 CT 测量存活肿瘤及邻近肝的定量参数。分析碘图中肿瘤增强值与各肿瘤灌注 CT 参数的相关性。测量双能 CT 和灌注 CT 的辐射剂量。
肝动脉期肿瘤的增强值高于正常肝实质（P<0.05）。肝动脉期碘图的肿瘤与肝比值最高。肿瘤肝血流高于邻近肝（P<0.05）。碘图中肝肿瘤的增强值与毛细血管表面通透性（r=0.913，P<0.001）、肝血流量（r=0.512，P=0.010）和肝血容量（r=0.464，P=0.022）呈正相关。灌注 CT 的有效辐射剂量高于 DECT（P<0.001）。
碘图中测量的存活肿瘤组织的增强值与兔 VX2 肝肿瘤的灌注 CT 测量值密切相关。与灌注 CT 相比，双能 CT 肝辐射剂量较低。
