Department of Psychiatry, University Medical Center Utrecht, P.B 85500, 3508 GA, Utrecht, The Netherlands.
Schizophr Res. 2011 Oct;132(1):84-90. doi: 10.1016/j.schres.2011.07.018. Epub 2011 Aug 10.
Evidence for an association between duration of untreated illness (DUI) with clinical and functional outcome or brain volume (change) in schizophrenia patients is inconclusive. We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients.
Magnetic resonance images were acquired at baseline (T0) and after 5-year (T5) of 57 schizophrenia patients. Correlations were calculated in patients between brain volume (change), DUI and outcome variables.
We found no significant correlation between DUI and brain volume (change) in schizophrenia patients. A longer DUI was significantly correlated with higher PANSS scores at T0 and T5, and with higher scores on the Camberwell Assessment of Need scale at T5. Baseline volume of the cerebrum and lateral ventricles, and cerebellum volume (change) were associated with PANSS scores at T0 and T5.
Although clinical outcome is associated with both brain volume (change) and DUI, we found no evidence for a relationship between DUI and brain volume (change). DUI and baseline brain volume or 5-year brain volume (change) seem to explain different parts of the variation in clinical outcome.
精神分裂症患者未治疗期（DUI）与临床和功能结局或脑体积（变化）之间的关联证据尚无定论。我们旨在研究首发精神分裂症患者发病时 DUI、结局和脑体积之间的关系，或在发病后 5 年内脑体积的变化。
对 57 例精神分裂症患者进行基线（T0）和 5 年（T5）时的磁共振成像检查。对患者的脑体积（变化）、DUI 和结局变量进行相关性计算。
我们发现精神分裂症患者的 DUI 与脑体积（变化）之间无显著相关性。较长的 DUI 与 T0 和 T5 时的 PANSS 评分较高，以及 T5 时的 Camberwell 需求评估量表评分较高相关。大脑、侧脑室和小脑的基线体积以及小脑体积（变化）与 T0 和 T5 时的 PANSS 评分相关。
尽管临床结局与脑体积（变化）和 DUI 均相关，但我们未发现 DUI 与脑体积（变化）之间存在关联。DUI 和基线脑体积或 5 年内脑体积（变化）似乎可以解释临床结局变化的不同部分。
