Department of Radiology, University of Pennsylvania, Philadelphia, 19104, USA.
Acad Radiol. 2011 Oct;18(10):1225-32. doi: 10.1016/j.acra.2011.06.009. Epub 2011 Aug 10.
The aim of this study was to assess the role of diffusion-weighted imaging in predicting progression-free survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with induction chemotherapy.
Eighteen patients with HNSCC underwent diffusion-weighted imaging studies prior to treatment and within 3 weeks after completion of induction chemotherapy. Median apparent diffusion coefficient (ADC) values were computed from the largest cervical metastatic lymph node. Percentage changes in ADC values from pretreatment to posttreatment time points were compared between alive and dead patients using the Mann-Whitney U test. P values < .05 were considered statistically significant.
A 22% increase in ADC was observed after induction chemotherapy in alive patients (n = 15), while patients who died from HNSCC (n = 3) demonstrated a 33% decrease in ADC. The difference in percentage change in ADC between alive and dead patients was significant (P = .039).
ADC may be a useful marker in predicting progression-free survival in patients with HNSCC undergoing induction chemotherapy.
本研究旨在评估弥散加权成像（DWI）在预测接受诱导化疗的头颈部鳞状细胞癌（HNSCC）患者无进展生存期（PFS）中的作用。
18 例 HNSCC 患者在治疗前和诱导化疗结束后 3 周内行 DWI 检查。从最大的颈部转移性淋巴结中计算出表观弥散系数（ADC）的中位数。采用曼-惠特尼 U 检验比较治疗前后 ADC 值变化百分比在存活和死亡患者之间的差异。P 值<0.05 被认为具有统计学意义。
在接受诱导化疗的存活患者（n=15）中，ADC 值增加了 22%，而死于 HNSCC 的患者（n=3）的 ADC 值则降低了 33%。存活和死亡患者之间 ADC 值变化百分比的差异具有统计学意义（P=0.039）。
在接受诱导化疗的 HNSCC 患者中，ADC 可能是预测 PFS 的一个有用标志物。
