[乳腺癌化疗前的卵母细胞/胚胎冷冻保存]

[Oocyte/embryo cryopreservation before chemotherapy for breast cancer].

作者信息

Decanter C, Gligorov J

机构信息

Service d'AMP de l'hôpital Jeanne-de-Flandre, centre de préservation ovarienne, CHRU de Lille, rue Eugène-Avinée, Lille cedex, France.

出版信息

Gynecol Obstet Fertil. 2011 Sep;39(9):501-3. doi: 10.1016/j.gyobfe.2011.07.011. Epub 2011 Aug 10.

DOI:10.1016/j.gyobfe.2011.07.011

PMID:21835668

Abstract

Breast cancer affects 6300 new patients per year under age 40 per year in France. The new adjuvant chemotherapy protocols have significantly improved the prognosis of these young women who may wish to conceive later. Embryo cryopreservation is the best way to preserve fertility, providing 25 to 35% chance of pregnancy. Oocyte freezing may be an alternative for single patients. This review will focus on: (1) ovarian toxicity of new adjuvant chemotherapy protocols, (2) the place of embryo or oocyte cryopreservation in fertility preservation techniques, (3) indications and protocols.

摘要

在法国，每年有6300名40岁以下的新乳腺癌患者。新的辅助化疗方案显著改善了这些可能希望日后怀孕的年轻女性的预后。胚胎冷冻保存是保留生育能力的最佳方法，怀孕几率为25%至35%。对于单身患者，卵母细胞冷冻可能是一种替代方法。本综述将聚焦于：（1）新辅助化疗方案的卵巢毒性；（2）胚胎或卵母细胞冷冻保存在生育力保存技术中的地位；（3）适应症和方案。