Ronald O Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center, New York, New York, USA.
Fertil Steril. 2012 Nov;98(5):1225-8. doi: 10.1016/j.fertnstert.2012.07.1056. Epub 2012 Aug 9.
To report the first case of fertility preservation in a premenarcheal female by use of controlled ovarian hyperstimulation and oocyte cryopreservation.
Case report.
Reproductive endocrinology and infertility unit of a tertiary care university-based medical center.
PATIENT(S): A 13-year-old premenarcheal female with Tanner stage 3 breast development and Tanner stage 1 pubic hair diagnosed with myelodysplastic syndrome, referred by her medical oncologist for fertility preservation before undergoing a potentially sterilizing antineoplastic therapy.
INTERVENTION(S): Evaluation of ovarian reserve, ovarian stimulation, transvaginal oocyte aspiration, in vitro maturation of immature oocytes, and oocyte cryopreservation.
MAIN OUTCOME MEASURE(S): Cryopreservation of mature oocytes.
RESULT(S): Successful controlled ovarian hyperstimulation allowed for the cryopreservation of 18 mature oocytes before the patient's gonadotoxic treatment. The oocyte retrieval and cryopreservation did not delay the patient's planned chemotherapy.
CONCLUSION(S): Ovarian stimulation and oocyte cryopreservation can be successfully performed in premenarcheal/peripubertal patients, thus providing a viable alternative to ovarian tissue freezing for fertility preservation in the pediatric population.
报告首例通过控制性卵巢超排卵和卵母细胞冷冻保存对青春期前女性进行生育力保存的案例。
病例报告。
三级甲等大学附属医院生殖内分泌和不孕不育科。
一名 13 岁的青春期前女性，乳房发育处于 Tanner 3 期，阴毛发育处于 Tanner 1 期，被其肿瘤内科医生诊断为骨髓增生异常综合征，为在接受潜在绝育性抗肿瘤治疗前进行生育力保存而转诊。
卵巢储备评估、卵巢刺激、阴道超声下卵母细胞抽吸、未成熟卵母细胞体外成熟和卵母细胞冷冻保存。
成熟卵母细胞的冷冻保存。
成功的控制性卵巢超排卵使患者在接受性腺毒性治疗前成功冷冻保存了 18 个成熟卵母细胞。卵母细胞采集和冷冻保存并未延迟患者计划中的化疗。
青春期前/青春期患者可以成功进行卵巢刺激和卵母细胞冷冻保存，因此为儿科人群的生育力保存提供了一种除卵巢组织冷冻以外的可行选择。
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