脂多糖A前体可抵御内毒素攻击。

Lipid A precursors protect against endotoxin challenge.

作者信息

Proctor R A

机构信息

Department of Medical Microbiology, University of Wisconsin Medical School, Madison 53706.

出版信息

Adv Exp Med Biol. 1990;256:641-52. doi: 10.1007/978-1-4757-5140-6_59.

DOI:10.1007/978-1-4757-5140-6_59

PMID:2183568

Abstract

These studies provide exciting prospects for the future treatment of gram-negative infections. The anti-endotoxin activity of lipid X, a monosaccharide precursor of lipid A, may be a prototypic compound for agents that can block the toxic effects of endotoxin that is being actively released. In contrast, monophosphoryl lipid A, a disaccharide derivative of lipid A, stimulates host defenses against infections and tumors. With further understanding of the mechanisms by which these compounds exert these effects, we can anticipate that new and more active compounds will be developed and that further activities of existing compounds will be found.

摘要

这些研究为革兰氏阴性菌感染的未来治疗提供了令人兴奋的前景。脂多糖A的单糖前体脂质X的抗内毒素活性，可能是一种能够阻断正在被主动释放的内毒素毒性作用的药物原型化合物。相比之下，脂多糖A的二糖衍生物单磷酰脂质A可刺激宿主抵御感染和肿瘤。随着对这些化合物发挥作用机制的进一步了解，我们可以预期将会开发出更新且更具活性的化合物，并且现有化合物会发现更多的活性。