一种脂多糖A前体对小鼠致死性内毒素血症的保护作用。
Protection of mice against lethal endotoxemia by a lipid A precursor.
作者信息
Proctor R A, Will J A, Burhop K E, Raetz C R
出版信息
Infect Immun. 1986 Jun;52(3):905-7. doi: 10.1128/iai.52.3.905-907.1986.
Abstract
Lipid X, the major biosynthetic precursor of lipid A, has recently been described. Although lipid X is a mitogen and coagulates the Limulus amebocyte lysate, we found that it is not lethal for mice, even when given in large doses (2 X 10(6) micrograms/kg). Furthermore, lipid X was found to give partial protection against a 100% lethal dose of endotoxin, even if the lipid X was given as late as 6 h after endotoxin challenge.
摘要
脂质X是脂质A的主要生物合成前体，最近已被描述。尽管脂质X是一种促细胞分裂剂，能使鲎变形细胞溶解物凝固，但我们发现它对小鼠并无致死性，即使大剂量给药（2×10⁶微克/千克）也是如此。此外，还发现脂质X能对100%致死剂量的内毒素提供部分保护，即使在毒素攻击6小时后才给予脂质X。
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