Soji T, Yashiro T, Herbert D C
Department of Anatomy, School of Medicine, Fukuoka University, Japan.
Anat Rec. 1990 Mar;226(3):337-41. doi: 10.1002/ar.1092260310.
The postnatal development of gap junction formation and cell-to-cell communication were investigated in male rats from 10 through 40 days of age. These junctions initially appeared between adjacent folliculo-stellate cells on day 20. Their numbers increased until the animals reached the age of 40 days, when their frequency reached a level that resembled that found in adults. The ontogeny of these junctions was examined in rats treated with luteinizing hormone releasing hormone (LH-RH) or testosterone. The two hormones were injected for 1 week into rats aged 3, 13, 23, or 33 days. The appearance of gap junctions was accelerated in a similar fashion by LH-RH and testosterone, with their formation and numbers being advanced by 10 days over that observed in the untreated controls. The results suggest a role for the gonadal steroid hormones in the formation of gap junctions in the rat hypophysis.
研究了10至40日龄雄性大鼠中缝隙连接形成和细胞间通讯的产后发育情况。这些连接最初在第20天出现在相邻的滤泡星状细胞之间。它们的数量不断增加，直到动物达到40日龄，此时其频率达到与成年动物相似的水平。在用促黄体生成素释放激素（LH-RH）或睾酮处理的大鼠中检查了这些连接的个体发育。将这两种激素注射到3、13、23或33日龄的大鼠体内1周。LH-RH和睾酮以类似的方式加速了缝隙连接的出现，其形成和数量比未处理的对照组提前了10天。结果表明性腺甾体激素在大鼠垂体缝隙连接的形成中起作用。
