小型综述：核激素受体及其配体对间隙连接动力学的调节
Minireview: regulation of gap junction dynamics by nuclear hormone receptors and their ligands.
作者信息
Firestone Gary L, Kapadia Bhumika J
机构信息
Department of Molecular and Cell Biology, 591 LSA, The University of California at Berkeley, Berkeley, California 94720-3200, USA.
出版信息
Mol Endocrinol. 2012 Nov;26(11):1798-807. doi: 10.1210/me.2012-1065. Epub 2012 Aug 30.
Abstract
Gap junctions are plasma membrane channels comprising connexin proteins that mediate intercellular permeability and communication. The presence, composition, and function of gap junctions can be regulated by diverse sets of physiological signals. Evidence from many hormone-responsive tissues has shown that connexin expression, modification, stability, and localization can be targeted by nuclear hormone receptors and their ligands through both transcriptional and nontranscriptional mechanisms. The focus of this review is to discuss molecular, cellular, and physiological studies that directly link receptor- and ligand-triggered signaling pathways to the regulation of gap junction dynamics.
摘要
间隙连接是由连接蛋白组成的质膜通道，介导细胞间的通透性和通讯。间隙连接的存在、组成和功能可受多种生理信号调控。来自许多激素反应性组织的证据表明，核激素受体及其配体可通过转录和非转录机制靶向连接蛋白的表达、修饰、稳定性和定位。本综述的重点是讨论将受体和配体触发的信号通路与间隙连接动力学调控直接联系起来的分子、细胞和生理学研究。
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2
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