在接受氨苄西林或头孢呋辛治疗的新生儿粪便大肠杆菌和克雷伯菌菌株中出现对β-内酰胺类抗生素的交叉耐药性。
Emergence of cross-resistance to beta-lactam antibiotics in fecal Escherichia coli and Klebsiella strains from neonates treated with ampicillin or cefuroxime.
作者信息
Tullus K, Berglund B, Burman L G
机构信息
Department of Pediatrics, Danderyd Hospital, Sweden.
出版信息
Antimicrob Agents Chemother. 1990 Feb;34(2):361-2. doi: 10.1128/AAC.34.2.361.
Abstract
Both ampicillin and cefuroxime therapy of neonates selected drug- and species-dependent beta-lactam resistance patterns in fecal strains of Escherichia coli and Klebsiella spp. This was in contrast to our previous findings that ampicillin, but not cefuroxime, contributed to the emergence of beta-lactam resistance also by the promotion of nosocomial spread of resistant strains.
摘要
氨苄西林和头孢呋辛对新生儿的治疗均在大肠杆菌和克雷伯菌属的粪便菌株中选择了药物和菌种依赖性的β-内酰胺耐药模式。这与我们之前的研究结果形成对比，即氨苄西林而非头孢呋辛通过促进耐药菌株的医院内传播也导致了β-内酰胺耐药性的出现。
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