孕中期羊膜腔穿刺术并非极低出生体重和超低出生体重的危险因素。
Second trimester amniocentesis is not a risk factor for very low birth weight and extremely low birth weight.
作者信息
Mazza Vincenzo, Pati Mariangela, Bertucci Emma, Cani Carlotta, Latella Silvia, Gargano Giancarlo, Percesepe Antonio, Volpe Annibale
机构信息
Prenatal Medicine Unit, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, 41121 Modena, Italy.
出版信息
ISRN Obstet Gynecol. 2011;2011:313206. doi: 10.5402/2011/313206. Epub 2011 Aug 3.
Objectives. To assess the risk of very low birth weight (VLBW) and extremely low birth weight (ELBW) attributable to second trimester amniocentesis. Methods. Records of 4,877 consecutive amniocentesis, performed between 1997 and 2003, were analyzed. Only VLBW and ELBW in the study population (exposed) and in the control group (unexposed) were evaluated. Comparisons were made between the amniocentesis group versus nonexposed. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for VLBW and ELBW classes. Results. In the study population, the VLBW were 35 (0.71%) and the ELBW were 20 (0.41%). In the control group, the VLBW were 220 (0.67%) and the ELBW were 112 (0.34%). The Odds ratios of the VLBW between the study and the control group did not show any statistical significant risk (OR = 1.07, 95% CI = 0.72-1.54). Also in ELBW odds ratios between study and control group were not statistically significant (OR = 1.20, 95% CI = 0.7-1.95). Conclusions. No effect of the second trimester amniocentesis was noted on VLBW and ELBW.
目的。评估孕中期羊膜腔穿刺术所致极低出生体重（VLBW）和超低出生体重（ELBW）的风险。方法。分析了1997年至2003年间连续进行的4877例羊膜腔穿刺术的记录。仅对研究人群（暴露组）和对照组（未暴露组）中的极低出生体重和超低出生体重进行评估。对羊膜腔穿刺术组与未暴露组进行比较。计算极低出生体重和超低出生体重类别的比值比（OR）和95%置信区间（95%CI）。结果。在研究人群中，极低出生体重儿有35例（0.71%），超低出生体重儿有20例（0.41%）。在对照组中，极低出生体重儿有220例（0.67%），超低出生体重儿有112例（0.34%）。研究组与对照组之间极低出生体重的比值比未显示出任何统计学显著风险（OR = 1.07，95%CI = 0.72 - 1.54）。研究组与对照组之间超低出生体重的比值比也无统计学意义（OR = 1.20，95%CI = 0.7 - 1.95）。结论。未观察到孕中期羊膜腔穿刺术对极低出生体重和超低出生体重有影响。
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