Tongsong T, Wanapirak C, Sirivatanapa P, Piyamongkol W, Sirichotiyakul S, Yampochai A
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
Obstet Gynecol. 1998 Jul;92(1):64-7. doi: 10.1016/s0029-7844(98)00125-2.
To assess the risk of fetal loss attributable to second-trimester amniocentesis.
A cohort study was undertaken among singleton pregnant women undergoing genetic amniocentesis and controls matched prospectively on a one-to-one basis, matched strictly for maternal age, parity, and socioeconomic status. Both groups were recruited at 15-24 weeks' gestation and observed until delivery. The fetal loss rates of the groups were compared.
A total of 2256 pairs were recruited to the study. After excluding those pairs lost to follow-up, those with fetal malformation, and those later proven to have major chromosomal abnormalities, 2045 matched pairs were compared by pregnancy outcomes. There were no significant differences in fetal loss rates, premature deliveries, or placental abruptions between the study and control groups (P > .05). However, this study did not have enough statistical power to identify differences of less than 1%.
Second-trimester amniocentesis is probably not associated with a greater fetal loss rate than that of matched controls.
评估孕中期羊膜腔穿刺术导致胎儿丢失的风险。
对接受基因羊膜腔穿刺术的单胎孕妇及前瞻性一对一匹配的对照组进行队列研究，严格按照孕妇年龄、产次和社会经济地位进行匹配。两组均在妊娠15 - 24周时入组，并观察至分娩。比较两组的胎儿丢失率。
共招募了2256对研究对象。在排除失访的对子、有胎儿畸形的对子以及后来证实有主要染色体异常的对子后，对2045对匹配对子的妊娠结局进行了比较。研究组和对照组在胎儿丢失率、早产或胎盘早剥方面无显著差异（P >.05）。然而，本研究没有足够的统计效能来识别小于1%的差异。
孕中期羊膜腔穿刺术导致的胎儿丢失率可能并不高于匹配对照组。
