Department of Obstetrics and Gynecology, School of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
Arch Gynecol Obstet. 2011 Dec;284(6):1473-9. doi: 10.1007/s00404-011-2047-y. Epub 2011 Aug 12.
To examine the current mechanisms of the increased incidence of cancer in women with endometriosis.
The synthesis and review of the relevant current literature in English language.
Compared with general population, women with endometriosis have two times higher risk for developing ovarian cancer, 30% higher risk for developing breast cancer, and 40% higher risk for developing hematopoietic malignancies, mainly non-Hodgkin lymphoma.
Endometriosis comprises many predisposing factors including genetic, epigenetic, local environmental, hormonal, inflammatory and immunologic changes, for the development of some cancers.
探讨子宫内膜异位症患者癌症发病率增高的当前机制。
对相关英文文献进行综合和综述。
与普通人群相比，子宫内膜异位症患者发生卵巢癌的风险增加两倍，乳腺癌风险增加 30%，血液系统恶性肿瘤（主要是非霍奇金淋巴瘤）风险增加 40%。
子宫内膜异位症包含许多促发因素，包括遗传、表观遗传、局部环境、激素、炎症和免疫改变，这些因素与某些癌症的发生有关。
