Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
Head Neck. 2011 Sep;33(9):1272-7. doi: 10.1002/hed.21594. Epub 2010 Nov 29.
The aim of this study was to evaluate the influence of coexistent Hashimoto's thyroiditis with papillary thyroid carcinoma on lymph node metastasis.
The coexistent Hashimoto's thyroiditis group was defined by the presence of thyroid autoantibodies or pathologic confirmation. The control group did not have autoantibodies, disease, or ultrasound findings of Hashimoto's thyroiditis.
For the Hashimoto's thyroiditis group, only central lymph node metastasis had a lower frequency and the mean number of central metastatic lymph nodes was lower than in the control group after adjustment. With regard to lateral lymph node involvement, there was no significant difference between the 2 groups. The multivariate analysis showed a negative association between the coexistence of Hashimoto's thyroiditis and central lymph node metastasis.
Coexisting Hashimoto's thyroiditis in patients with papillary thyroid carcinoma was identified as a negative independent predictive factor for central lymph node metastasis.
本研究旨在评估桥本甲状腺炎与甲状腺乳头状癌并存对淋巴结转移的影响。
桥本甲状腺炎组的定义为存在甲状腺自身抗体或病理证实。对照组无自身抗体、疾病或桥本甲状腺炎的超声表现。
对于桥本甲状腺炎组，只有中央淋巴结转移的频率较低，且经调整后中央转移性淋巴结的平均数量也低于对照组。至于侧方淋巴结受累，两组间无显著差异。多变量分析显示桥本甲状腺炎的共存与中央淋巴结转移呈负相关。
甲状腺乳头状癌合并桥本甲状腺炎被确定为中央淋巴结转移的阴性独立预测因子。
