Merkel 细胞癌中肽基脯氨酰顺反异构酶过表达与患者总生存率的显著相关性。
Significant correlation of peptidyl-prolyl isomerase overexpression in Merkel cell carcinoma with overall survival of patients.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Medical University of Vienna, Austria.
出版信息
Head Neck. 2011 Sep;33(9):1294-300. doi: 10.1002/hed.21596. Epub 2010 Nov 29.
BACKGROUND
An overexpression of PIN1, the peptidyl-prolyl cis-trans isomerase, might cause cell cycle arrest and growth inhibition by binding to the p53 protein, a process leading to p53 stabilization. The rationale of this retrospective analysis was to evaluate the expression pattern of PIN1 in Merkel cell carcinomas (MCCs) and its suitability as a prognostic factor.
METHODS
Samples of 27 MCCs were immunhistochemically stained for PIN1 expression and correlated with overall and disease-free survival of patients.
RESULTS
All samples expressed PIN1. We showed a significantly better overall survival in patients with an overexpression of PIN1 than in patients with a weak PIN1 expression (p = .031), but expression was not significant for disease-free survival (p = .821). The 5-year overall survival rate was 14.4% in patients with weak and 50.9% in patients with overexpression of PIN1.
CONCLUSIONS
PIN1 seems to be a prognostic factor for a better overall survival rate of patients with MCC.
背景
肽基脯氨酰顺反异构酶 PIN1 的过表达可能通过与 p53 蛋白结合导致细胞周期停滞和生长抑制，这一过程导致 p53 稳定。本回顾性分析的基本原理是评估 PIN1 在 Merkel 细胞癌 (MCC) 中的表达模式及其作为预后因素的适宜性。
方法
对 27 例 MCC 样本进行 PIN1 表达的免疫组织化学染色，并与患者的总生存率和无病生存率相关联。
结果
所有样本均表达 PIN1。与 PIN1 弱表达的患者相比，PIN1 过表达的患者总生存率显著提高（p =.031），但无病生存率无显著差异（p =.821）。PIN1 弱表达患者的 5 年总生存率为 14.4%，PIN1 过表达患者的 5 年总生存率为 50.9%。
结论
PIN1 似乎是 MCC 患者总生存率较好的预后因素。
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