Kovác J, Kovác D
Klinika stomatológie a maxilofaciálnej chirurgie LFUK a OULSA Bratislava, Slovenská republika.
Epidemiol Mikrobiol Imunol. 2011 Jun;60(2):77-86.
Periapical lesions are among the most frequently diagnosed apical odontogenic pathologies in human teeth. The condition is generally described as apical periodontitis. Apical periodontitis is a sequel to endodontic infection and manifests itself as the host defense response to microbial challenge emanating from the root canal system to the periapical tissue. It is viewed as a dynamic encounter between microbial factors and host defenses at the interface between infected radicular pulp and periodontal ligament that results in local inflammation, resorption of hard tissues, destruction of other periapical tissues, and eventual formation of various histopathological categories of apical periodontitis, commonly referred to as periapical lesions. There are also factors located within the inflamed periapical tissue that can interfere with post-treatment healing of the lesion. The purpose of this article is to provide a comprehensive overview of the etiopathogenesis of apical periodontitis and causes of failed endodontic treatment. This study presents a histopathological analysis through optical microscopy of periapical lesions, commonly referred to as solid dental or periapical granuloma.
根尖周病变是人类牙齿中最常被诊断出的根尖牙源性病变之一。这种情况通常被描述为根尖周炎。根尖周炎是牙髓感染的后遗症，表现为宿主对从根管系统扩散到根尖周组织的微生物挑战的防御反应。它被视为在感染的牙髓和牙周膜之间的界面处微生物因素与宿主防御之间的动态相互作用，导致局部炎症、硬组织吸收、其他根尖周组织破坏，最终形成各种组织病理学类型的根尖周炎，通常称为根尖周病变。在发炎的根尖周组织中也存在一些因素，它们可能会干扰病变治疗后的愈合。本文的目的是全面概述根尖周炎的病因发病机制以及牙髓治疗失败的原因。本研究通过光学显微镜对根尖周病变（通常称为实性牙或根尖周肉芽肿）进行了组织病理学分析。
