Omoregie F O, Ojo M A, Saheeb Bdo, Odukoya O
Department of Oral and Maxillofacial Surgery and Pathology, University of Benin, Benin City, Nigeria.
Niger J Clin Pract. 2011 Jul-Sep;14(3):293-6. doi: 10.4103/1119-3077.86770.
This article aims to determine the incidence of periapical granuloma from extracted teeth and correlate the clinical diagnoses with the histopathological types of periapical granuloma.
Over a period of eight months, a prospective study designed as a routine biopsy of recoverable periapical tissues obtained from patients who had single tooth extraction was carried out.
One hundred and thirty-six patients participated in the study, with 75 (55.1%) histopathologically diagnosed periradicular lesions. There were 23 (16.9%) cases of periapical granuloma, with a male to female ratio of 2: 1. The lesion presented mostly between the third and fourth decades of life (n=9, 6.6%). Clinically diagnosed acute apical periodontitis was significantly associated with periapical granuloma, with predominantly foamy macrophages and lymphocytes (P<0.05).
Periapical granuloma appears to be a less common periapical lesion in this study compared to the previous reports. In contrast to reports that relate to an acute flare of the lesion with abundant neutrophilic infiltration, this study has shown marked foamy macrophages and lymphocytes at the acute phase, which are significantly associated with the clinical diagnosis of acute apical periodontitis. We recommend the classification of periapical granuloma into early, intermediate, and late stages of the lesion, based on the associated inflammatory cells.
本文旨在确定拔牙后根尖周肉芽肿的发生率，并将临床诊断与根尖周肉芽肿的组织病理学类型相关联。
在八个月的时间里，开展了一项前瞻性研究，该研究设计为对单颗牙拔除患者可回收的根尖周组织进行常规活检。
136名患者参与了该研究，其中75名（55.1%）经组织病理学诊断为根尖周病变。有23例（16.9%）根尖周肉芽肿病例，男女比例为2:1。病变大多出现在生命的第三个和第四个十年之间（n = 9，6.6%）。临床诊断为急性根尖周炎与根尖周肉芽肿显著相关，主要表现为泡沫状巨噬细胞和淋巴细胞（P<0.05）。
与先前的报告相比，在本研究中根尖周肉芽肿似乎是一种不太常见的根尖周病变。与有关病变急性发作伴大量中性粒细胞浸润的报告不同，本研究显示急性期有明显的泡沫状巨噬细胞和淋巴细胞，这与急性根尖周炎的临床诊断显著相关。我们建议根据相关炎症细胞将根尖周肉芽肿分为病变的早期、中期和晚期。
