Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Maheshnagar, Pimpri, Pune 411 018, Maharashtra, India.
Oral Oncol. 2011 Dec;47(12):1110-6. doi: 10.1016/j.oraloncology.2011.06.513. Epub 2011 Aug 12.
In WHO classification of odontogenic tumors (2005), juvenile ossifying fibroma (JOF) is divided into juvenile psammomatoid ossifying fibroma (JPOF) and juvenile trabecular ossifying fibroma (JTOF). JPOF has been distinguished because of its location, clinical behavior, and age of occurrence. It is generally seen in younger age group and the most common site is paranasal sinuses, orbits, and fronto-ethmoidal complex. Radiologically, the internal structure can be radiolucent, mixed, or radiopaque, depending on the degree of calcification and extent of the cystic changes. Histologically, it is characterized by a densely cellular fibrous stroma interspersed with numerous psammoma bodies. The treatment is "en bloc" surgical excision while in case of intracranial extension, tumor removal may need a combination of neurosurgical and transfacial approach. Malignant transformation and metastasis has not been reported but recurrence is common. The purpose of this narrative review article is to discuss the various aspects of JPOF reported in the English medical literature.
在世界卫生组织(WHO)的牙源性肿瘤分类(2005 年)中,青少年骨化性纤维瘤(JOF)分为青少年沙砾体样骨化性纤维瘤(JPOF)和青少年小梁骨化性纤维瘤(JTOF)。JPOF 因其位置、临床行为和发病年龄而被区分开来。它通常发生在年轻人群中,最常见的部位是鼻窦、眼眶和额筛复合体。放射学上,根据钙化程度和囊变程度的不同,内部结构可以是透亮的、混合的或不透射线的。组织学上,其特征是密集的细胞纤维基质中散布着许多沙粒体。治疗方法是“整块”手术切除,而对于颅内延伸的情况,肿瘤切除可能需要神经外科和经面联合入路。尚未报道恶性转化和转移,但复发常见。本文的目的是讨论在英文医学文献中报道的 JPOF 的各个方面。