Clinic of Cardiology, Pomeranian Medical University, Szczecin, Poland.
Arch Med Res. 2011 Jul;42(5):426-32. doi: 10.1016/j.arcmed.2011.08.002. Epub 2011 Aug 12.
Inflammation plays a key role in the development of atherosclerosis. We investigated associations between the interleukin-1β gene (IL1B) and IL-1 receptor antagonist (IL1RN ) polymorphisms and their haplotypes, with coronary artery disease (CAD), severity of CAD (single vessel, SVD vs. multivessel disease, MVD) and hypertension.
Three hundred eighteen individuals were submitted to coronary angiography. Of these, 201 patients with ≥50% occlusion in at least one major coronary artery comprised the CAD group; the control group (non-CAD) consisted of the remaining 117 subjects. The genotypes of IL1B C(-31)T and IL1RN VNTR were determined by polymerase chain reaction (PCR).
Allele (-31)C of the IL1B gene was significantly associated with hypertension (p = 0.046). There was no association of hypertension with IL1RN genotype. The association between the number of IL1B C alleles and prevalence of hypertension was similar in univariate (OR 1.383; 95% CI 1.002-1.909; p = 0.048) and multivariate (OR 1.429; 95% CI 1.021-1.999; p = 0.036) analysis. We did not observe a significant association between CAD and genotypes or alleles of IL1B C(-31)T/IL1RN VNTR or their haplotypes. No associations were found between IL1B C(-31)T or IL1RN VNTR genotypes, alleles or haplotypes and the severity of CAD when subgroups with SVD and MVD were compared.
No association was found between polymorphisms of IL1B C(-31)T/IL1RN VNTR or their haplotypes and CAD. However, the data suggest that allele (-31)C of IL1B may be a risk factor for hypertension in the Polish population with CAD in the western Pomeranian region of Poland.
炎症在动脉粥样硬化的发生发展中起着关键作用。我们研究了白细胞介素-1β基因（IL1B）和白细胞介素-1受体拮抗剂（IL1RN）多态性及其单倍型与冠状动脉疾病（CAD）、CAD 严重程度（单支血管病变，SVD 与多支血管病变，MVD）和高血压之间的关系。
318 名患者接受冠状动脉造影检查。其中，201 名至少有一条主要冠状动脉≥50%闭塞的患者为 CAD 组；对照组（非 CAD 组）包括其余 117 名患者。采用聚合酶链反应（PCR）法检测 IL1B C（-31）T 和 IL1RN VNTR 基因型。
IL1B 基因的等位基因（-31）C 与高血压显著相关（p=0.046）。IL1RN 基因型与高血压无相关性。在单变量（OR 1.383；95%CI 1.002-1.909；p=0.048）和多变量（OR 1.429；95%CI 1.021-1.999；p=0.036）分析中，IL1B C 等位基因数量与高血压的相关性相似。我们未观察到 CAD 与 IL1B C（-31）T/IL1RN VNTR 基因型或等位基因或其单倍型之间存在显著相关性。当比较 SVD 和 MVD 亚组时，未发现 IL1B C（-31）T 或 IL1RN VNTR 基因型、等位基因或单倍型与 CAD 严重程度之间存在相关性。
IL1B C（-31）T/IL1RN VNTR 多态性或其单倍型与 CAD 之间无相关性。然而，数据表明，IL1B 的等位基因（-31）C 可能是波兰西部波美拉尼亚地区波兰 CAD 人群高血压的一个危险因素。
