Polymorphism of Interleukin 1B May Modulate the Risk of Ischemic Stroke in Polish Patients.

: Inflammation plays a crucial role in the pathophysiology of ischemic stroke (IS). Interleukin-1B and interleukin-1 receptor antagonists are key factors in inflammatory processes. Aims: The aims of our study were to evaluate the relationship between genetic variation in interleukin-1B () rs1143627 and interleukin-1 receptor antagonist () variable-number-tandem-repeats (VNTR), and overall IS and subtype prevalence rates. The analysis included 147 hospitalized Polish patients with IS diagnosed using conventional criteria. The control group consisted of 119 healthy subjects. Genotypes were determined by polymerase chain reaction. A significant association between rs1143627 and stroke was found. The -31C polymorphism showed an association with overall IS, OR = 2.30 (1.36-3.87) = 0.020. An association was also detected for LVI (large vessel infarction) subtypes of stroke. After risk factor adjustment (age, diabetes mellitus, dyslipidemia), the C allele was found to be an independent risk factor for LVI, OR = 1.99 (1.05-3.79) = 0.036. Significant association was not observed between alleles and IS. Our results suggest that the C allele of rs1143627 may be associated with susceptibility to overall IS and LVI subtypes of stroke in the Polish population.