Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
Department of General and Dental Radiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Medicina (Kaunas). 2019 Sep 2;55(9):558. doi: 10.3390/medicina55090558.
: Inflammation plays a crucial role in the pathophysiology of ischemic stroke (IS). Interleukin-1B and interleukin-1 receptor antagonists are key factors in inflammatory processes. Aims: The aims of our study were to evaluate the relationship between genetic variation in interleukin-1B () rs1143627 and interleukin-1 receptor antagonist () variable-number-tandem-repeats (VNTR), and overall IS and subtype prevalence rates. The analysis included 147 hospitalized Polish patients with IS diagnosed using conventional criteria. The control group consisted of 119 healthy subjects. Genotypes were determined by polymerase chain reaction. A significant association between rs1143627 and stroke was found. The -31C polymorphism showed an association with overall IS, OR = 2.30 (1.36-3.87) = 0.020. An association was also detected for LVI (large vessel infarction) subtypes of stroke. After risk factor adjustment (age, diabetes mellitus, dyslipidemia), the C allele was found to be an independent risk factor for LVI, OR = 1.99 (1.05-3.79) = 0.036. Significant association was not observed between alleles and IS. Our results suggest that the C allele of rs1143627 may be associated with susceptibility to overall IS and LVI subtypes of stroke in the Polish population.
炎症在缺血性中风（IS）的病理生理学中起着关键作用。白细胞介素-1B 和白细胞介素-1 受体拮抗剂是炎症过程中的关键因素。目的：我们研究的目的是评估白细胞介素-1B () rs1143627 与白细胞介素-1 受体拮抗剂 () 可变数目串联重复 (VNTR) 的遗传变异与总体 IS 和亚型患病率之间的关系。该分析包括 147 名使用常规标准诊断为 IS 的住院波兰患者。对照组由 119 名健康受试者组成。通过聚合酶链反应确定基因型。rs1143627 与中风之间存在显著相关性。-31C 多态性与总体 IS 相关，OR = 2.30（1.36-3.87）= 0.020。还检测到 LVI（大血管梗死）中风亚型的相关性。在危险因素调整（年龄、糖尿病、血脂异常）后，C 等位基因被发现是 LVI 的独立危险因素，OR = 1.99（1.05-3.79）= 0.036。等位基因与 IS 之间未观察到显著相关性。我们的结果表明，波兰人群中 rs1143627 的 C 等位基因可能与总体 IS 和 LVI 中风亚型的易感性相关。
