Institute of Brain Science, National Yang-Ming University, Taipei 11221, Taiwan.
Neuroscience. 2011 Oct 27;194:27-35. doi: 10.1016/j.neuroscience.2011.08.007. Epub 2011 Aug 6.
Hippocampal theta wave can be induced by running and is linked to cognitive functions. The initiation and maintenance of hippocampal theta during a complete course of running, however, is not well understood. Using a treadmill exercise model, this study wirelessly recorded the hippocampal electroencephalogram, nuchal electromyogram, electrocardiogram, and three-dimensional accelerations of 15 male young rats. Although the speed of the treadmill was constant during the entire 30-min running course, the frequency (Frq) and amplitude (Amp) of hippocampal theta changed dynamically. During the first 24 s (phase I), the Frq, Amp, electromyogram amplitude (EMG), heart rate (HR), and physical activity (PA) all increased. The changes in the Frq, EMG, and PA were among the fastest and the change in the HR was the slowest. After 24 s (phase II), the Frq declined to near baseline but the Amp remained persistently high. The slope of the Frq, Amp, and HR over time during phase I was different to that during phase II. During phase II, the Frq and Amp were significantly correlated with the PA and EMG. We conclude that treadmill running can be classified into two phases based on hippocampal functioning, and hippocampal theta varies with exercise effort during the treadmill running.
海马体θ波可以通过跑步来诱发，并且与认知功能有关。然而，在完整的跑步过程中，海马体θ波的起始和维持还不是很清楚。本研究使用跑步机运动模型，无线记录了 15 只雄性幼鼠的海马脑电图、颈肌电图、心电图和三维加速度。尽管在整个 30 分钟的跑步过程中跑步机的速度保持不变，但海马体θ波的频率（Frq）和振幅（Amp）却在动态变化。在最初的 24 秒（第一阶段）中，Frq、Amp、肌电图振幅（EMG）、心率（HR）和身体活动（PA）均增加。Frq、EMG 和 PA 的变化最快，HR 的变化最慢。24 秒后（第二阶段），Frq 下降到接近基线，但 Amp 仍然持续升高。第一阶段和第二阶段中 Frq、Amp 和 HR 的时间变化斜率不同。在第二阶段，Frq 和 Amp 与 PA 和 EMG 显著相关。我们得出结论，根据海马体的功能，跑步机跑步可以分为两个阶段，并且在跑步机跑步过程中，海马体θ波随运动强度而变化。
