Department of Health and Leisure Management, Yuanpei University of Medical Technology, Hsinchu, Taiwan; Sleep Research Center, National Yang-Ming University, Taipei, Taiwan.
Sleep Research Center, National Yang-Ming University, Taipei, Taiwan; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; Brain Research Center, National Yang-Ming University, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan.
Behav Brain Res. 2021 Feb 5;399:112916. doi: 10.1016/j.bbr.2020.112916. Epub 2020 Sep 16.
Regular exercise promotes learning and memory functions. Theta activity is known to relate to various cognitive functions. An increase in theta power may be related to higher cognitive functioning and learning functions. However, evidence is lacking to directly confirm that exercise training can increase the theta activity and promote various cognitive functions simultaneously. We hypothesize that long-term voluntary exercise increases the activity of hippocampal theta rhythm and enhances memory behavior. We used the voluntary wheel running model and a training period of 8 weeks. We started the training when the rats were 12 weeks old. Before and after intervention, we performed a 24 -h electrophysiological recording and 8-arm radial maze test to analyze the hippocampal theta rhythm in awake stage, and spatial memory functions. We discovered that middle to high range frequency (6.5-12 Hz) of theta power was increased after exercise intervention. In addition, the working memory error of 8-arm radial maze test in the exercise group decreased significantly after the 8 weeks of treatment, and these reductions were negatively correlated with hippocampal theta activity. Our results demonstrate that 8-weeks voluntary exercise increases both hippocampal theta amplitude and spatial memory in the rats.
规律运动可促进学习和记忆功能。已知θ波活动与各种认知功能有关。θ波功率的增加可能与更高的认知功能和学习功能有关。然而，目前缺乏直接证据证实运动训练可以同时增加θ波活动并促进各种认知功能。我们假设长期的自愿运动可以增加海马θ节律的活动，并增强记忆行为。我们使用了自愿轮跑模型和 8 周的训练期。我们从大鼠 12 周龄时开始训练。在干预前后，我们进行了 24 小时的电生理记录和 8 臂放射状迷宫测试，以分析清醒状态下的海马θ节律和空间记忆功能。我们发现，运动干预后，θ功率的中频到高频（6.5-12 Hz）增加。此外，8 臂放射状迷宫测试的工作记忆错误在 8 周治疗后显著减少，并且这些减少与海马θ活动呈负相关。我们的结果表明，8 周的自愿运动可以增加大鼠的海马θ振幅和空间记忆。
