Uteshev B S, Korostelev S A
Farmakol Toksikol. 1990 Jan-Feb;53(1):10-6.
The data on the central mechanisms of the immune system regulation and the role of opioid peptides in this process are summarized. The fact that the opioid component is involved in the regulation of the system of immunity predetermines the possibility of the influence on the immune system by means of the compounds possessing the opioid activity. This fact and also their low toxicity make the compounds promising for the development on their basis of original immunomodulators devoid of the disadvantages being intrinsic to the available drugs.
总结了免疫系统调节的中枢机制以及阿片肽在此过程中的作用的数据。阿片类成分参与免疫系统调节这一事实决定了通过具有阿片活性的化合物影响免疫系统的可能性。这一事实以及它们的低毒性使得这些化合物有望在此基础上开发出没有现有药物固有缺点的新型免疫调节剂。
