Tricerri A, Errani A R, Vangeli M, Guidi L, Pavese I, Antico L, Bartoloni C
Istituto di Medicina Interna Geriatrica, Universita Cattolica del Sacro Cuore, Rome, Italy.
Panminerva Med. 1995 Jun;37(2):77-83.
In recent years the relationships among immune, endocrine and nervous systems have been extensively studied, and grouped in a new research field: psychoneuro-immunoendocrinology. Since ancient times its has been known that, in humans, mood as well as environmental influences could affect health. In the late '70s, only, evidence of bi-directional pathways has been achieved, first in animal models and, later on, in humans. We reviewed current knowledge on neuroimmunomodulation, concerning the influence of stress and psychological status on immunity as well as neuroendocrine modulation by the immune system, reporting some data obtained from our studies. Particularly, having detected a relevant impairment concerning most of the parameters studied, we emphasized the effects of depressive disorders on immune function in the elderly.
近年来，免疫、内分泌和神经系统之间的关系得到了广泛研究，并被归为一个新的研究领域：心理神经免疫内分泌学。自古以来，人们就知道，在人类中，情绪以及环境影响都会影响健康。直到20世纪70年代末，才首次在动物模型中，随后在人类中获得了双向通路的证据。我们回顾了当前关于神经免疫调节的知识，涉及压力和心理状态对免疫的影响以及免疫系统对神经内分泌的调节，并报告了我们研究中获得的一些数据。特别是，在检测到所研究的大多数参数存在相关损害后，我们强调了抑郁症对老年人免疫功能的影响。
