冷传导中的冷通道。
A cool channel in cold transduction.
机构信息
Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.
出版信息
Physiology (Bethesda). 2011 Aug;26(4):273-85. doi: 10.1152/physiol.00004.2011.
PMID:21841075
Abstract
Transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel activated by cold, cooling compounds and voltage, is the main molecular entity responsible for detection of cold temperatures in the somatosensory system. Here, we review the biophysical properties, physiological role, and near-membrane trafficking of this exciting polymodal ion channel.
摘要
瞬时受体电位 melastatin 8（TRPM8）是一种钙通透性阳离子通道，可被冷、冷却化合物和电压激活，是负责躯体感觉系统中冷温度检测的主要分子实体。在这里，我们回顾了这种令人兴奋的多模态离子通道的生物物理特性、生理作用和近膜运输。
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