子宫切除术后18年患者出现子宫内膜样腺癌：雌激素替代治疗的潜在风险
Endometrioid adenocarcinoma presenting in a patient 18 years after hysterectomy: a potential hazard of unopposed oestrogen therapy.
作者信息
Ronga Alvaro Bedoya, Najia Salim K, Sahasrabudhe Neil, Prescott Richard, Buruiana Felicia Elena, Heazell Alexander
机构信息
Stoke Mandeville Hospital, Obstetrics and Gynaecology, Flat C, 17-19 Guildford Street, Luton LU1 2NQ, UK.
出版信息
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.05.2009.1829. Epub 2009 Aug 13.
Abstract
We present a case of endometrioid adenocarcinoma arising from extragonadal endometriosis 18 years after total abdominal hysterectomy with bilateral salpingo-oophorectomy. After the primary surgery the patient received 11 years of unopposed oestrogen hormone replacement therapy. She presented with symptoms of urinary retention and pelvic mass. Following resection, histopathology identified the mass as an endometrioid adenocarcinoma. The association between persistent endometriosis and the development of endometrial cancer are discussed here together with the risks of unopposed oestrogen in the development of such lesions.
摘要
我们报告一例在全腹子宫切除加双侧输卵管卵巢切除术后18年发生于性腺外子宫内膜异位症的子宫内膜样腺癌病例。初次手术后，患者接受了11年的单纯雌激素激素替代疗法。她出现了尿潴留和盆腔肿块的症状。切除术后，组织病理学检查确定肿块为子宫内膜样腺癌。本文讨论了持续性子宫内膜异位症与子宫内膜癌发生之间的关联，以及单纯雌激素在这类病变发生中的风险。
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