Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Adv Exp Med Biol. 2011;780:143-59. doi: 10.1007/978-1-4419-5632-3_12.
The realization of a major role for events that occur during acute viremia that dictate the course of disease both in HIV-1 infected humans and susceptible SIV infected non-human primates has prompted an intense interest in studies of the contribution of innate immune effector mechanisms. It is reasoned that findings from such studies may be important and need to be incorporated into the design and formulation of potential candidate vaccines against HIV-1. This review serves to outline the various non-human primate models that can best serve to address this issue, a summary of our knowledge on the various subsets of NK cells (one of the major innate immune cell lineage) that have an impact on the course of disease, the potential pathways that regulate their function and the potential role of the KIRs on SIV-induced disease course. Finally, the major points from this report and the data presented on similar subjects by other investigators is utilized to provide a summary of the potential future directions that we need to take in efforts to move this field forward.
急性病毒血症期间发生的事件对人类感染 HIV-1 和易感的非人类灵长类动物感染 SIV 疾病进程都起着重要作用，这一发现促使人们对固有免疫效应机制的作用产生了浓厚的兴趣。人们推断，这些研究结果可能很重要，需要纳入针对 HIV-1 的潜在候选疫苗的设计和制定中。本综述旨在概述可用于解决这一问题的各种非人类灵长类动物模型，概述对疾病进程有影响的各种 NK 细胞（主要固有免疫细胞谱系之一）亚群的知识，调节其功能的潜在途径以及 KIR 在 SIV 诱导的疾病进程中的潜在作用。最后，利用本报告中的要点和其他研究人员在类似主题上提供的数据，总结我们需要努力推动该领域前进的潜在未来方向。
