Institut Pasteur, Unité HIV, Inflammation and Persistence, Paris, France; CEA, Division of Immuno-Virology, iMETI, DSV, Fontenay-aux-Roses, France; Vaccine Research Institute, Créteil, France.
Institut Pasteur, Unité HIV, Inflammation and Persistence, Paris, France; Vaccine Research Institute, Créteil, France.
Curr Opin Virol. 2016 Aug;19:37-44. doi: 10.1016/j.coviro.2016.06.011. Epub 2016 Jul 20.
HIV-1/SIVmac infections deeply disturb innate host responses. Most studies have focused on the impact on dendritic cells and NK cells. A few but insufficient data are available on other innate immune cell types, such as neutrophils. It has been shown that innate lymphoid cells are depleted early and irreversibly during SIVmac/HIV-1 infections. Studies in natural hosts of SIV have contributed to pinpoint that early control of inflammation is crucial. In natural hosts, plasmacytoid dendritic cells, myeloid dendritic cells and NK cells are depleted during acute infection but return to normal levels by the end of acute infection. We summarize here the similarities and differences of various types of innate immune responses in natural hosts compared to pathogenic HIV/SIV mac infections.
HIV-1/SIVmac 感染会严重扰乱固有宿主的反应。大多数研究都集中在树突状细胞和 NK 细胞的影响上。关于其他固有免疫细胞类型（如中性粒细胞）的资料很少且不充分。已经表明，在 SIVmac/HIV-1 感染期间，先天淋巴细胞会被早期且不可逆地耗尽。SIV 天然宿主的研究有助于确定早期控制炎症至关重要。在天然宿主中，浆细胞样树突状细胞、髓样树突状细胞和 NK 细胞在急性感染期间被耗尽，但在急性感染结束时恢复到正常水平。在这里，我们总结了天然宿主与致病性 HIV/SIVmac 感染相比，各种固有免疫反应的异同。
