Pathology Unit, Department of Oncology, University Scientific Institute San Raffaele, Milan, Italy.
Semin Diagn Pathol. 2011 May;28(2):161-6. doi: 10.1053/j.semdp.2011.02.014.
Chronic lymphocytic leukemia (CLL), an indolent B-cell malignancy frequently diagnosed in the elderly, is characterized by the relentless accumulation of CD5+ monoclonal B cells that proliferate in the appropriate tissue microenvironments. Despite many advances achieved by molecular and functional studies, our knowledge of the reciprocal relationship between the CLL cell and its microenvironment at the tissue level is still largely incomplete. In this review we present the relevant current information on the tissue microenvironmental features of CLL, focusing on the events that appear to occur in the lymph node. Special attention is devoted to analyzing the properties of both neoplastic and nonneoplastic bystander cells within proliferation centers, the mysterious structures that likely represent the actual proliferative compartment.
慢性淋巴细胞白血病（CLL）是一种惰性 B 细胞恶性肿瘤，常见于老年人，其特征是不断积累 CD5+单克隆 B 细胞，这些细胞在适当的组织微环境中增殖。尽管通过分子和功能研究取得了许多进展，但我们对 CLL 细胞与其组织水平微环境之间的相互关系的了解仍然很不完整。在这篇综述中，我们介绍了有关 CLL 组织微环境特征的相关最新信息，重点介绍了似乎发生在淋巴结中的事件。特别关注分析增殖中心内肿瘤和非肿瘤旁观者细胞的特性，这些神秘结构可能代表实际的增殖区室。
