Matsui M, Matsuzaki M, Shimamoto Y, Shigyo M, Uchida M, Ono K, Sano M, Sakemi T, Yamaguchi M
Department of Internal Medicine, Saga Medical School.
Rinsho Ketsueki. 1990 Feb;31(2):229-33.
A case of non-Hodgkin's lymphoma with nephrotic syndrome and acute renal failure is described. A 60-year-old Japanese male was admitted to our hospital in November, 1988, because of lymphadenopathy, fever, night sweat, weight loss. On physical examination, lymphadenopathy was present in both cervical, submandibular, supraclavicular, axillary and inguinal regions. The leukocyte count was 9,700/microliters with 85% neutrophils and 2% atypical lymphocytes. Renal function was normal. Lymph node biopsy showed non-Hodgkin's lymphoma of diffuse, large cell type. Immunohistologic examination showed T cell type. A few days later, he fell into acute renal failure. After systemic chemotherapy, he showed prompt improvement in renal function. Echo and computerized tomography (CT) of abdomen revealed no compression of the ureters and bladder. Renal biopsy findings suggested mesangium proliferative glomerulonephritis without invasion of tumor cells. Our case seemed to be rare and was compared with previous reports.
本文描述了一例伴有肾病综合征和急性肾衰竭的非霍奇金淋巴瘤病例。一名60岁的日本男性于1988年11月因淋巴结病、发热、盗汗、体重减轻入住我院。体格检查发现双侧颈部、颌下、锁骨上、腋窝和腹股沟区均有淋巴结病。白细胞计数为9700/微升，中性粒细胞占85%，非典型淋巴细胞占2%。肾功能正常。淋巴结活检显示为弥漫性大细胞型非霍奇金淋巴瘤。免疫组织学检查显示为T细胞型。几天后，他陷入急性肾衰竭。全身化疗后，他的肾功能迅速改善。腹部超声和计算机断层扫描（CT）显示输尿管和膀胱无受压。肾活检结果提示系膜增生性肾小球肾炎，无肿瘤细胞浸润。我们的病例似乎很罕见，并与以前的报告进行了比较。
