Cognitive Neuroscience Unit, IRCCS San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25123 Brescia, Italy.
Int J Psychophysiol. 2011 Sep;81(3):312-6. doi: 10.1016/j.ijpsycho.2011.07.017. Epub 2011 Aug 16.
The effects of sleep deprivation on neural activity underlying stimulus change detection are still debated. The aim of this study was to investigate the effects of sleep deprivation on the relationship between N1 refractoriness and Mismatch Negativity (MMN) as indexes of different stages of change detection. Respectively, N1 represents the sensory feature trace creation with stimulus repetition and MMN represents the memory-based detection of deviance in a new incoming stimulus. Event-related potentials (ERPs) were recorded from 22 healthy participants during a passive auditory oddball task after a night of normal sleep and after a night of total sleep deprivation (TSD). Importantly, stimulus presentation was organized as a train of 10 stimuli, so that N1 refractoriness could be measured as amplitude decrease with stimulus repetition within each train. Results showed that N1 refractoriness and MMN were not affected by TSD suggesting that the change detection process was preserved in our paradigm. However, the overall N1 amplitude increased after TSD, an effect that may be related to an enhancement of cortical excitability.
睡眠剥夺对刺激变化检测下神经活动的影响仍存在争议。本研究旨在探讨睡眠剥夺对 N1 不应期和失匹配负波 (MMN) 之间关系的影响，N1 不应期反映了刺激重复时的感觉特征痕迹形成，而 MMN 则反映了新传入刺激中偏差的基于记忆的检测。分别在正常睡眠后的一晚和完全睡眠剥夺 (TSD) 后的一晚，对 22 名健康参与者在被动听觉Oddball 任务中记录了事件相关电位 (ERP)。重要的是，刺激呈现组织为 10 个刺激的序列，因此可以在每个序列内测量 N1 不应期，即随着刺激重复，振幅降低。结果表明，N1 不应期和 MMN 不受 TSD 的影响，这表明我们的实验范式中变化检测过程得到了保留。然而，在 TSD 后，N1 的总体振幅增加，这种效应可能与皮质兴奋性的增强有关。
