School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
Biotechnol Adv. 2012 Mar-Apr;30(2):440-8. doi: 10.1016/j.biotechadv.2011.07.018. Epub 2011 Aug 7.
As commercial approval of the first, purified, plant-based biopharmaceuticals for parenteral delivery to humans approaches, improved strategies for delivery of plant-made vaccines and therapeutics are required to ensure their further development and to fulfil the prospect of supplying a global solution for affordable medicines. To ensure that this occurs, research should investigate and characterise the host immune system in addition to the effects of adjuvants and carrier vehicles on consistency and efficacy of vaccination. In this review we explore the basic understandings of pharmaceutical delivery and its effect on immunogenicity in an effort to advance the plant-made pharmaceutical platform.
随着第一种经商业批准的、用于人体肠胃外给药的纯化植物生物制药的出现，需要改进植物制造的疫苗和疗法的传递策略，以确保它们的进一步发展，并实现提供负担得起的全球药物解决方案的前景。为了确保这一点的发生，研究应该调查和描述宿主免疫系统，以及佐剂和载体对疫苗接种一致性和功效的影响。在这篇综述中，我们探讨了药物传递的基本理解及其对免疫原性的影响，以推进植物制造的药物平台。
