a Research Center for Pharmaceutical Nanotechnology; Tabriz University of Medical Science; Tabriz, Iran.
Hum Vaccin Immunother. 2014;10(8):2497-502. doi: 10.4161/hv.29032.
Despite worldwide vaccination against devastating diseases for decades, millions of children in remote and impoverished regions of the globe die every year from vaccine-preventable infectious diseases. The reasons for incomplete coverage of vaccination programs are based in part on the relatively high costs of conventional vaccinations, including mass production, refrigeration, transportation, and training as well as funding personnel for their administration. Plant-based edible vaccines (PEVs) have been introduced as a revolutionary cost-effective vaccination modality. However, they suffer from major deficiencies that have restricted their application to bench-scale. This article discusses the deficiencies of PEVs and also provides concise overview on the health-promoting, biological and biotechnological features of spirulina (Arthrospira). In short, we envision that spirulina could be considered as a potential alternative biofactory system to the plants toward the production of edible vaccines in high-yield with low-costs that other hosts cannot yet offer.
尽管几十年来全球范围内一直在针对毁灭性疾病进行疫苗接种，但每年仍有全球偏远和贫困地区的数百万儿童死于可通过疫苗预防的传染病。疫苗接种计划覆盖不完全的部分原因是常规疫苗接种的相对较高成本，包括大规模生产、冷藏、运输、培训以及为其接种提供资金的人员。植物源性可食用疫苗 (PEV) 的出现是一种具有成本效益的革命性疫苗接种模式。然而，它们存在一些主要缺陷，限制了它们在实验室规模上的应用。本文讨论了 PEV 的缺陷，并对螺旋藻（Arthrospira）的保健、生物和生物技术特性进行了简要概述。简而言之，我们设想可以将螺旋藻视为植物的潜在替代生物工厂系统，用于生产高产量、低成本的可食用疫苗，而其他宿主目前还无法提供。
