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产后三个时期放置左炔诺孕酮宫内节育系统:前瞻性随机初步研究。

Postpartum insertion of levonorgestrel--intrauterine system at three time periods: a prospective randomized pilot study.

机构信息

Department of Obstetrics and Gynecology, The Naval Medical Center Portsmouth, VA 23708, USA.

出版信息

Contraception. 2011 Sep;84(3):244-8. doi: 10.1016/j.contraception.2011.01.007. Epub 2011 Feb 24.

Abstract

BACKGROUND

The study was conducted to determine the feasibility of levonorgestrel-intrauterine system (LNG-IUS) insertion at three different times postpartum.

STUDY DESIGN

From August 2009 to January 2010, all women desiring LNG-IUS for postpartum contraception were offered enrollment into our study and randomized to three insertion times: immediate (within 10 min of placenta delivery), early (10 min to 48 h postpartum) or interval (≥6 weeks postpartum).

RESULTS

Forty-six women met inclusion criteria and were analyzed. There was no difference in utilization rates at 3 and 6 months between groups (p=.931). Expulsion rates were significantly higher and pain during insertion was significantly lower in the immediate and early groups (p<.001) when compared to the interval group.

CONCLUSION

Insertion of LNG-IUS ≤48 h postpartum is feasible in our institution and may be associated with similar utilization at 6 months, increased expulsion rates and decreased pain at insertion when compared to placement after 6 weeks.

摘要

背景

本研究旨在确定在产后三个不同时间点植入左炔诺孕酮宫内节育系统(LNG-IUS)的可行性。

研究设计

从 2009 年 8 月至 2010 年 1 月,所有希望使用 LNG-IUS 进行产后避孕的女性均被纳入本研究并随机分为三组:即刻(胎盘娩出后 10 分钟内)、早期(产后 10 分钟至 48 小时)或间隔(≥6 周后)。

结果

46 名符合纳入标准的女性被纳入分析。三组在产后 3 个月和 6 个月的使用率无差异(p=.931)。与间隔组相比,即刻和早期组的脱落率明显更高,插入时的疼痛明显更低(p<.001)。

结论

在本机构,产后≤48 小时内植入 LNG-IUS 是可行的,与 6 周后放置相比,6 个月时的使用率可能相似,脱落率增加,插入时的疼痛减轻。

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