Department of Clinical Biochemistry, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK.
Diabetes Care. 2011 Oct;34(10):2217-9. doi: 10.2337/dc11-0533. Epub 2011 Aug 15.
To assess random venous blood glucose (RBG) measurement at antenatal booking to detect "overt diabetes in pregnancy" (ODIP).
A retrospective analysis of regional hospital obstetric data from 2004-2008 was performed. Universal RBG screening was included at booking. Oral glucose tolerance test (OGTT) was administered if RBG >7.0 mmol/L or other indications, e.g., if a 50-g glucose challenge test was >7.7 mmol/L at 26-28 weeks. ODIP was based upon World Health Organization plasma glucose criteria for diabetes.
RBG data were collected from 17,852/26,369 (67.7%) pregnancies around the initial antenatal visit; 3,007 women had an OGTT. The receiver operator curve area under the curve for RBG to detect ODIP was 0.86 (0.80-0.92) (assuming women without an OGTT did not have ODIP).
RBG at booking may provide a sufficiently sensitive screening tool for the detection of ODIP. We recommend further studies and comparison with fasting glucose and HbA(1c).
评估产前预约时的随机静脉血糖（RBG）测量值，以检测“妊娠期显性糖尿病”（ODIP）。
对 2004 年至 2008 年期间区域性医院的产科数据进行了回顾性分析。预约时进行通用 RBG 筛查。如果 RBG＞7.0mmol/L 或存在其他指征（例如，26-28 周时 50g 葡萄糖挑战试验＞7.7mmol/L），则进行口服葡萄糖耐量试验（OGTT）。ODIP 基于世界卫生组织糖尿病血浆葡萄糖标准。
在初始产前检查时，从 17852/26369（67.7%）例妊娠中收集了 RBG 数据；3007 名妇女进行了 OGTT。RBG 检测 ODIP 的受试者工作特征曲线下面积为 0.86（0.80-0.92）（假设未进行 OGTT 的妇女没有 ODIP）。
预约时的 RBG 可能是一种检测 ODIP 的足够敏感的筛查工具。我们建议进一步研究并与空腹血糖和 HbA1c 进行比较。
