Tollefson Travis T, Kamangar Faranak, Aminpour Shervin, Lee Andrew, Durbin-Johnson Blythe, Tinling Steven
Department of Otolaryngology-Head and Neck Surgery, University of California, Davis Medical Center, 2521 Stockton Blvd., Sacramento, CA 95817, USA.
Arch Facial Plast Surg. 2012 Jan-Feb;14(1):45-51. doi: 10.1001/archfacial.2011.62. Epub 2011 Aug 15.
To determine the effectiveness of treating scars with microporous paper tape or silicone gel sheeting (SGS) in preventing hypertrophic scarring.
Forty hypertrophic scars were induced in a validated rabbit ear model. Wounds were randomized and bandaged for 30 days with either SGS (20 wounds), paper tape (20 wounds), or untreated controls (40 wounds). Two outcome measures of hypertrophic scarring included (1) histologic measurement of scar elevation index (SEI) and (2) blinded photograph analysis using a visual analog scale.
In histologic comparison, no difference in mean (SE) SEI between treatment groups was seen (paper tape group, 1.32 [0.2]; SGS group, 1.41 [0.18]; control, 1.35 [0.23]; P = .51). In photographic analysis, both treatment groups were superior to the control group (P < .01), whereas no difference was seen between the SGS and paper tape groups (P = .88).
Paper tape and SGS demonstrated equal effectiveness in the prevention of hypertrophic scarring on visual analysis, whereas histologic analysis demonstrated no difference in treatment groups from controls. The effectiveness of paper tape in preventing hypertrophic scarring in humans will require further laboratory and clinical investigation.
确定微孔纸胶带或硅胶片（SGS）治疗瘢痕预防增生性瘢痕形成的有效性。
在经过验证的兔耳模型中诱导形成40处增生性瘢痕。将伤口随机分组，分别用SGS（20处伤口）、纸胶带（20处伤口）包扎30天，或不做处理作为对照（40处伤口）。增生性瘢痕的两项结局指标包括：（1）瘢痕隆起指数（SEI）的组织学测量；（2）使用视觉模拟量表进行盲法照片分析。
组织学比较显示，各治疗组之间的平均（SE）SEI无差异（纸胶带组，1.32 [0.2]；SGS组，1.41 [0.18]；对照组，1.35 [0.23]；P = 0.51）。照片分析显示，两个治疗组均优于对照组（P < 0.01），而SGS组和纸胶带组之间无差异（P = 0.88）。
视觉分析表明，纸胶带和SGS在预防增生性瘢痕形成方面效果相当，而组织学分析显示治疗组与对照组无差异。纸胶带预防人类增生性瘢痕形成的有效性需要进一步的实验室和临床研究。
