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硅胶粘合剂在减少疤痕方面的应用。

The Use of Silicone Adhesives for Scar Reduction.

作者信息

Bleasdale Benjamin, Finnegan Simon, Murray Kathyryn, Kelly Sean, Percival Steven L

机构信息

Scapa Healthcare , Manchester, United Kingdom .

Department of Chemistry, University of Sheffield , Sheffield, United Kingdom .

出版信息

Adv Wound Care (New Rochelle). 2015 Jul 1;4(7):422-430. doi: 10.1089/wound.2015.0625.


DOI:10.1089/wound.2015.0625
PMID:26155385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4486716/
Abstract

This article discusses the history and developments of silicone gel sheeting (SGS) scar therapy. Furthermore, we review a breadth of literature to gain an insight into how and why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance. Topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed at present. However, there still is ongoing deliberation over the exact mechanism of action of silicone in improving a scar. At present it is likely that through occlusion of the scar site and hydration of the wound bed, the overactivity of scar-related cells is suppressed, and their activity normalized. The clinical support of topical silicone gel products, relative to all alternative scar therapies, is considered the internationally recommended first-line form of scar management, and favored by consensus among healthcare professionals. However, there still remains the need for further clinical evidence and a better understanding of the mechanism behind the benefit of silicone gel for use in the prevention of abnormal scarring.

摘要

本文讨论了硅胶片(SGS)瘢痕治疗的历史与发展。此外,我们查阅了大量文献,以深入了解局部用硅胶凝胶如何以及为何仍然是医学专家在瘢痕管理中最青睐的治疗方法。我们还分析了越来越多声称能提供更好瘢痕减轻效果的替代疗法。局部用硅胶凝胶治疗似乎仍是瘢痕管理临床推荐的首要选择。SGS已用于瘢痕治疗30多年,在此期间其疗效一直是众多临床评估的主题。虽然SGS改善增生性瘢痕、瘢痕疙瘩形成及恢复的确切机制尚未完全达成共识,但目前其有此作用的能力在很大程度上是无可争议的。然而,对于硅胶改善瘢痕的确切作用机制仍在进行讨论。目前,可能是通过封闭瘢痕部位和使创面床水化,抑制了瘢痕相关细胞的过度活跃,并使其活性正常化。相对于所有替代瘢痕疗法,局部用硅胶凝胶产品的临床支持被认为是国际推荐的瘢痕管理一线方式,且受到医疗保健专业人员的一致青睐。然而,仍需要进一步的临床证据,并更好地理解硅胶凝胶预防异常瘢痕形成益处背后的机制。

相似文献

[1]
The Use of Silicone Adhesives for Scar Reduction.

Adv Wound Care (New Rochelle). 2015-7-1

[2]
Evolution of silicone therapy and mechanism of action in scar management.

Aesthetic Plast Surg. 2008-1

[3]
The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema.

Aesthetic Plast Surg. 2007

[4]
A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management.

Dermatol Surg. 2007-11

[5]
Comparative effect of topical silicone gel and topical tretinoin cream for the prevention of hypertrophic scar and keloid formation and the improvement of scars.

J Eur Acad Dermatol Venereol. 2014-8

[6]
Silicone occlusive treatment of hypertrophic scar in the rabbit model.

Aesthet Surg J. 2002-3

[7]
The role of the epidermis in the control of scarring: evidence for mechanism of action for silicone gel.

J Plast Reconstr Aesthet Surg. 2008-10

[8]
A prospective placebo-controlled study on the efficacy of onion extract in silicone derivative gel for the prevention of hypertrophic scar and keloid in median sternotomy wound in pediatric patients.

J Med Assoc Thai. 2013-11

[9]
Real-world management of abnormal scarring using topical silicone gel: expert consensus and case series from the Asian SCARS Expert Group.

Drugs Context. 2023-7-3

[10]
Phase 2 cross-over multicenter trial on the efficacy and safety of topical cyanoacrylates compared with topical silicone gel in the prevention of pathologic scars.

Aesthetic Plast Surg. 2010-11-16

引用本文的文献

[1]
Outcomes of Microsurgical Reconstruction of Post-Burn Joint Contracture-Systematic Review and Meta-Analysis.

Microsurgery. 2025-9

[2]
Evidence-Based Topical Therapy for Facial Scars in Diverse Skin Types.

Cureus. 2025-6-19

[3]
Recent Advances in the Local Drug Delivery Systems for Diabetic Wound Healing: A Comprehensive Review.

AAPS PharmSciTech. 2025-7-1

[4]
Comparative Efficacy of Silicone Sheets and Hyperbaric Oxygen Therapy in Post-Surgical Scar Prevention: A Prospective Observational Study.

Int J Med Sci. 2025-2-11

[5]
Eyelid Reconstruction.

Semin Plast Surg. 2024-12-17

[6]
Evidence Supporting Conservative Scar Management Interventions Following Burn Injury: A Review Article.

J Burn Care Res. 2025-8-12

[7]
Microneedling in Dermatology: A Comprehensive Review of Applications, Techniques, and Outcomes.

Cureus. 2024-9-23

[8]
Role of Dermatix in the Management of Eyelid Hypertrophic Scars After Facial Trauma.

Cureus. 2024-5-31

[9]
Efficacy of Silicone Gel in Healing of Lacerated Wounds in Maxillofacial Region-An Experimental Study.

J Maxillofac Oral Surg. 2024-6

[10]
Pharmacotherapy for Keloids and Hypertrophic Scars.

Int J Mol Sci. 2024-4-25

本文引用的文献

[1]
Management of scars: updated practical guidelines and use of silicones.

Eur J Dermatol. 2014

[2]
Update on hypertrophic scar treatment.

Clinics (Sao Paulo). 2014-8

[3]
Combination therapy in the management of atrophic acne scars.

J Cutan Aesthet Surg. 2014-1

[4]
Analysis of frequency of use of different scar assessment scales based on the scar condition and treatment method.

Arch Plast Surg. 2014-3

[5]
Silicone gel sheeting for preventing and treating hypertrophic and keloid scars.

Cochrane Database Syst Rev. 2013-9-12

[6]
The safety, efficacy, and tolerability of a novel silicone gel dressing following dermatological surgery.

Skinmed. 2012

[7]
Linear scar reduction using silicone gel sheets in individuals with normal healing.

J Wound Care. 2012-12

[8]
Wound repair and regeneration.

Eur Surg Res. 2012

[9]
Ablative fractional resurfacing for the treatment of traumatic scars and contractures.

Semin Cutan Med Surg. 2012-6

[10]
Comparison of effectiveness of silicone gel sheeting with microporous paper tape in the prevention of hypertrophic scarring in a rabbit model.

Arch Facial Plast Surg. 2012

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