Bleasdale Benjamin, Finnegan Simon, Murray Kathyryn, Kelly Sean, Percival Steven L
Scapa Healthcare , Manchester, United Kingdom .
Department of Chemistry, University of Sheffield , Sheffield, United Kingdom .
Adv Wound Care (New Rochelle). 2015 Jul 1;4(7):422-430. doi: 10.1089/wound.2015.0625.
This article discusses the history and developments of silicone gel sheeting (SGS) scar therapy. Furthermore, we review a breadth of literature to gain an insight into how and why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance. Topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed at present. However, there still is ongoing deliberation over the exact mechanism of action of silicone in improving a scar. At present it is likely that through occlusion of the scar site and hydration of the wound bed, the overactivity of scar-related cells is suppressed, and their activity normalized. The clinical support of topical silicone gel products, relative to all alternative scar therapies, is considered the internationally recommended first-line form of scar management, and favored by consensus among healthcare professionals. However, there still remains the need for further clinical evidence and a better understanding of the mechanism behind the benefit of silicone gel for use in the prevention of abnormal scarring.
本文讨论了硅胶片(SGS)瘢痕治疗的历史与发展。此外,我们查阅了大量文献,以深入了解局部用硅胶凝胶如何以及为何仍然是医学专家在瘢痕管理中最青睐的治疗方法。我们还分析了越来越多声称能提供更好瘢痕减轻效果的替代疗法。局部用硅胶凝胶治疗似乎仍是瘢痕管理临床推荐的首要选择。SGS已用于瘢痕治疗30多年,在此期间其疗效一直是众多临床评估的主题。虽然SGS改善增生性瘢痕、瘢痕疙瘩形成及恢复的确切机制尚未完全达成共识,但目前其有此作用的能力在很大程度上是无可争议的。然而,对于硅胶改善瘢痕的确切作用机制仍在进行讨论。目前,可能是通过封闭瘢痕部位和使创面床水化,抑制了瘢痕相关细胞的过度活跃,并使其活性正常化。相对于所有替代瘢痕疗法,局部用硅胶凝胶产品的临床支持被认为是国际推荐的瘢痕管理一线方式,且受到医疗保健专业人员的一致青睐。然而,仍需要进一步的临床证据,并更好地理解硅胶凝胶预防异常瘢痕形成益处背后的机制。
Adv Wound Care (New Rochelle). 2015-7-1
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